4-[3-(1H-imidazol-5-yl)propyl]piperidine profile

ID Source	ID
PubMed CID	10330240
CHEMBL ID	78498
CHEBI ID	93084
SCHEMBL ID	15139142

Synonym
vuf-5681
CHEMBL78498 ,
BRD-K62206109-303-01-1
NCGC00167742-01
AKOS006290761
bdbm50409817
4-[3-(1h-imidazol-4-yl)-propyl]-piperidine
SCHEMBL15139142
768358-61-8
vuf 5681
CHEBI:93084
4-[3-(1h-imidazol-4-yl)propyl]piperidine
4-[3-(1h-imidazol-5-yl)propyl]piperidine
Q7907645
4-(3-(1h-imidazol-4-yl)propyl)piperidine
DTXSID501277310
4-(3-(1h-imidazol-5-yl)propyl)piperidine
WR5V5TB2TR
piperidine, 4-(3-(1h-imidazol-5-yl)propyl)-
piperidine, 4-(3-(1h-imidazol-4-yl)propyl)-

Class	Description
aralkylamine	An alkylamine in which the alkyl group is substituted by an aromatic group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (3)

Potency Measurements

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
DNA polymerase kappa isoform 1	Homo sapiens (human)	Potency	15.0030	0.0316	22.3146	100.0000	AID588579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Histamine H4 receptor	Homo sapiens (human)	Ki	1,621,809,954,816.0000	0.0006	0.4787	10.0000	AID90039
Histamine H3 receptor	Homo sapiens (human)	Ki	0.0045	0.0001	0.3399	8.5110	AID1282213; AID86615; AID86619
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Histamine H4 receptor	Homo sapiens (human)	EC50 (µMol)	10.0000	0.0074	0.6016	10.0000	AID90035
Histamine H3 receptor	Homo sapiens (human)	EC50 (µMol)	0.0083	0.0000	0.0947	3.1623	AID86478
Histamine H3 receptor	Homo sapiens (human)	Kd	0.0079	0.0001	0.0138	0.0631	AID86474
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (9)

Process	via Protein(s)	Taxonomy
inflammatory response	Histamine H4 receptor	Homo sapiens (human)
positive regulation of cytosolic calcium ion concentration	Histamine H4 receptor	Homo sapiens (human)
biological_process	Histamine H4 receptor	Homo sapiens (human)
regulation of MAPK cascade	Histamine H4 receptor	Homo sapiens (human)
G protein-coupled serotonin receptor signaling pathway	Histamine H4 receptor	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	Histamine H4 receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Histamine H4 receptor	Homo sapiens (human)
chemical synaptic transmission	Histamine H4 receptor	Homo sapiens (human)
neurotransmitter secretion	Histamine H3 receptor	Homo sapiens (human)
G protein-coupled serotonin receptor signaling pathway	Histamine H3 receptor	Homo sapiens (human)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	Histamine H3 receptor	Homo sapiens (human)
chemical synaptic transmission	Histamine H3 receptor	Homo sapiens (human)
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	Histamine H3 receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (3)

Process	via Protein(s)	Taxonomy
histamine receptor activity	Histamine H4 receptor	Homo sapiens (human)
G protein-coupled serotonin receptor activity	Histamine H4 receptor	Homo sapiens (human)
G protein-coupled acetylcholine receptor activity	Histamine H4 receptor	Homo sapiens (human)
histamine receptor activity	Histamine H3 receptor	Homo sapiens (human)
G protein-coupled acetylcholine receptor activity	Histamine H3 receptor	Homo sapiens (human)
G protein-coupled serotonin receptor activity	Histamine H3 receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (4)

Process	via Protein(s)	Taxonomy
plasma membrane	Histamine H4 receptor	Homo sapiens (human)
plasma membrane	Histamine H4 receptor	Homo sapiens (human)
dendrite	Histamine H4 receptor	Homo sapiens (human)
synapse	Histamine H4 receptor	Homo sapiens (human)
plasma membrane	Histamine H3 receptor	Homo sapiens (human)
presynapse	Histamine H3 receptor	Homo sapiens (human)
plasma membrane	Histamine H3 receptor	Homo sapiens (human)
synapse	Histamine H3 receptor	Homo sapiens (human)
dendrite	Histamine H3 receptor	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (15)

Assay ID	Title	Year	Journal	Article
AID86620	Selectivity is the ratio of inhibitory activity against Histamine H3 receptor to that of Histamine H4 receptor	2003	Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25	Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
AID86615	Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells	2004	Journal of medicinal chemistry, May-06, Volume: 47, Issue:10	Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist.
AID1282213	Displacement of [3H]-NR-methylhistamine from human histamine H3 receptor expressed in SK-N-MC cells by liquid scintillation counter	2016	Journal of medicinal chemistry, Feb-11, Volume: 59, Issue:3	Tactical Approaches to Interconverting GPCR Agonists and Antagonists.
AID86474	Inhibition of the cAMP-stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H3 receptor	2004	Journal of medicinal chemistry, May-06, Volume: 47, Issue:10	Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H(3) receptor agonist.
AID90035	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H4 receptor	2003	Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25	Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
AID86455	Intrinsic activity determined towards Histamine H3 receptor	2003	Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25	Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
AID90039	Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H4 receptor	2003	Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25	Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
AID89904	Intrinsic activity for Histamine H4 receptor; not determined	2003	Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25	Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
AID86619	Inhibitory activity measured by [3H]- N alpha- methyl-histamine binding to membranes of SK-N-MC cells expressing the human Histamine H3 receptor	2003	Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25	Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
AID86478	Inhibitory activity determined by the inhibition of cAMP- stimulated beta-galactosidase transcription in SK-N-MC cells expressing the human Histamine H3 receptor	2003	Journal of medicinal chemistry, Dec-04, Volume: 46, Issue:25	Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists.
AID1508628	Confirmatory qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1508629	Cell Viability qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1508630	Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1508627	Counterscreen qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: GLuc-NoTag assay	2021	Cell reports, 04-27, Volume: 35, Issue:4	A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347154	Primary screen GU AMC qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (40.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	2 (40.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
histamine [no description available]	2.01	1	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter
n(6)-(3-iodobenzyl)-5'-n-methylcarboxamidoadenosine N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine: structure given in first source; a selective A(3) adenosine receptor agonist. 3-iodobenzyl-5'-N-methylcarboxamidoadenosine : A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and one of the hydrogens of the exocyclic amino function is substituted by a 3-iodobenzyl group.	3.23	1	adenosines; monocarboxylic acid amide; organoiodine compound	adenosine A3 receptor agonist
2-chloro-n(6)cyclopentyladenosine 2-chloro-N(6)cyclopentyladenosine: highly selective agonist at A1 adenosine receptors	3.23	1
alpha-methylhistamine (R)-alpha-methylhistamine : An aralkylamino compound that is histamine bearing a methyl substituent at the alpha-position (the R-enantiomer).	2.01	1	aralkylamino compound; imidazoles	H3-receptor agonist
olmesartan olmesartan: an active metabolite of CS 866	3.23	1	biphenylyltetrazole	angiotensin receptor antagonist; antihypertensive agent
imidazolyl-4-propylamine imidazolyl-4-propylamine: structure given in first source	2.01	1
n(6)-cyclopentyladenosine [no description available]	3.23	1
4-(1h-imidazol-4-ylmethyl)piperidine 4-(1H-imidazol-4-ylmethyl)piperidine: structure in first source	3.83	3	piperidines
2-chloro-n(6)-(3-iodobenzyl)adenosine-5'-n-methyluronamide 2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide: structure given in first source	3.23	1
nalorphine Nalorphine: A narcotic antagonist with some agonist properties. It is an antagonist at mu opioid receptors and an agonist at kappa opioid receptors. Given alone it produces a broad spectrum of unpleasant effects and it is considered to be clinically obsolete.	3.23	1	morphinane alkaloid
morphine Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.	3.23	1	morphinane alkaloid; organic heteropentacyclic compound; tertiary amino compound	anaesthetic; drug allergen; environmental contaminant; geroprotector; mu-opioid receptor agonist; opioid analgesic; plant metabolite; vasodilator agent; xenobiotic
fr 190997 FR 190997: structure given in first source	3.23	1
impentamine impentamine: structure in first source	2.01	1
sr 14150 SR 14150: mixed NOP and mu-opioid receptor ligand and antinociceptive; structure in first source	3.23	1
4-(1H-imidazol-5-ylmethyl)pyridine [no description available]	2.02	1	pyridines
4-(1h-imidazol-4-yl)butanamine 4-(1H-imidazol-4-yl)butanamine: agonist of both H3 and H4 histamine receptors; structure in first source	2.42	2

Condition	Relationship Strength	Studies
Muscle Contraction A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.	2.02	1
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.25	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1

4-[3-(1H-imidazol-5-yl)propyl]piperidine

Cross-References

Synonyms (20)

Drug Classes (1)

Protein Targets (3)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (9)

Molecular Functions (3)

Ceullar Components (4)

Bioassays (15)

Research

Studies (5)

Market Indicators

Research Demand Index: 12.87

Study Types

4-[3-(1H-imidazol-5-yl)propyl]piperidine

Cross-References

Synonyms (20)

Drug Classes (1)

Protein Targets (3)

Potency Measurements

Inhibition Measurements

Activation Measurements

Biological Processes (9)

Molecular Functions (3)

Ceullar Components (4)

Bioassays (15)

Research

Studies (5)

Market Indicators

Research Demand Index: 12.87

Study Types

Related Drugs (16)

Related Conditions (4)